Lack of association between human switch recombination breakpoints and the secondary structure of targeted DNA regions.
نویسندگان
چکیده
منابع مشابه
Analysis of immunoglobulin Sgamma3 recombination breakpoints by PCR: implications for the mechanism of isotype switching.
The molecular mechanism of immunoglobulin switch recombination is poorly understood. Switch recombination occurs between pairs of switch regions located upstream of the constant heavy chain genes. Previously we showed that switch recombination breakpoints cluster to a defined subregion in the Sgamma3, Sgamma1 and Sgamma2b tandem repeats. We have developed a strategy for direct amplification of ...
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ورودعنوان ژورنال:
- Journal of immunology
دوره 172 5 شماره
صفحات -
تاریخ انتشار 2004